Back to Search
Start Over
Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect
- Source :
- Clinical and Translational Medicine, Clinical and Translational Medicine, Vol 8, Iss 1, Pp 1-17 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Berlin Heidelberg, 2019.
-
Abstract
- Background Several investigations affirm that, patients with inflammatory bowel disease (IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial composition intertwined with immune dysregulation. The interaction between stem cells and gut microbiota is a novel and highly promising field that could add up to a better understanding of the gut physiology, as well as therapeutic improvement towards diseases like IBD. Through direct contact or release of products and/or metabolites, gut bacteria regulate gut homeostasis, damage repair, regeneration and differentiation of stem cells. In the same way, mesenchymal stem cells (MSCs) produce similar effects including restoration of gut–microbiome composition. Body We reviewed the anti-inflammatory, antimicrobial, pathogenic bacterial clearance, proliferation and tissue remodeling effects of mesenchymal stem cells (MSCs) and fecal microbiota transplantation (FMT) as separate transplants in IBD, and the outcome of the interaction between MSCs and gut microbiota. Conclusion The two therapies share several points of connection in therapeutics with enhanced functionalities in their interaction with each other. Focused investigations of MSC–gut bacteria interactions could lead to a novel discovery in therapeutics. We also anticipate an improved clinical remission rate in a combined FMT–MSC transplantation approach in IBD than the current single FMT or MSC approach.
- Subjects :
- 0301 basic medicine
Medicine (miscellaneous)
Review
Gut flora
medicine.disease_cause
Fecal microbiota transplant
Inflammatory bowel disease
digestive system
03 medical and health sciences
0302 clinical medicine
medicine
lcsh:R5-920
biology
Regeneration (biology)
Mesenchymal stem cell
Immune dysregulation
medicine.disease
biology.organism_classification
Transplantation
030104 developmental biology
MSC–gut bacteria interaction
030220 oncology & carcinogenesis
Immunology
Molecular Medicine
Mesenchymal stem cell therapy
Stem cell
lcsh:Medicine (General)
Dysbiosis
Combined therapy
Subjects
Details
- Language :
- English
- ISSN :
- 20011326
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Medicine
- Accession number :
- edsair.doi.dedup.....7c81839869cd27dbf9dd2824e5e30f09