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The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home
- Source :
- Curr Opin Microbiol
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Intravacuolar bacterial pathogens establish intracellular niches by constructing membrane-encompassed compartments. The vacuoles surrounding the bacteria are remarkably stable, facilitating microbial replication and preventing exposure to host cytoplasmically-localized innate immune sensing mechanisms. To maintain integrity of the membrane compartment, the pathogen is armed with defensive weapons that prevent loss of vacuole integrity and potential exposure to host innate signaling. In some cases, the microbial components that maintain vacuolar integrity have been identified, but the basis for why the compartment degrades in their absence is unclear. In this review, we point out that lessons from the microbial-programmed degradation of the vacuole by the cytoplasmically-localized Shigella flexneri provide critical insights into how degradation of pathogen vacuoles occurs. We propose that in the absence of bacterial-encoded guard proteins, aberrant trafficking of host membrane-associated components results in a dysfunctional pathogen compartment. As a consequence, the vacuole is poisoned and replication is terminated.
- Subjects :
- Microbiology (medical)
Virulence Factors
Chlamydia trachomatis
Vacuole
Microbiology
Article
Legionella pneumophila
Shigella flexneri
03 medical and health sciences
Bacterial Proteins
Gram-Negative Bacteria
Autophagy
Humans
Sorting Nexins
Pathogen
030304 developmental biology
0303 health sciences
Innate immune system
biology
030306 microbiology
Extramural
biology.organism_classification
Cell biology
Infectious Diseases
Multiprotein Complexes
Host-Pathogen Interactions
Vacuoles
Intracellular
Subjects
Details
- ISSN :
- 13695274
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Microbiology
- Accession number :
- edsair.doi.dedup.....7c7c285618602fe87336efd140a40c75