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Pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide in cats after oral, intravenous, and intraperitoneal administration of cyclophosphamide
- Source :
- American Journal of Veterinary Research. 78:862-866
- Publication Year :
- 2017
- Publisher :
- American Veterinary Medical Association (AVMA), 2017.
-
Abstract
- OBJECTIVE To characterize pharmacokinetics of cyclophosphamide and 4-hydoxycyclophosphamide (4-OHCP) in the plasma of healthy cats after oral, IV, and IP administration of cyclophosphamide. ANIMALS 6 healthy adult cats. PROCEDURES Cats were randomly assigned to receive cyclophosphamide (200 mg/m2) via each of 3 routes of administration (oral, IV, and IP); there was a 30-day washout period between successive treatments. Plasma samples were obtained at various time points for up to 8 hours after administration. Samples were treated with semicarbazide hydrochloride to trap the 4-OHCP in stable form, which allowed for cyclophosphamide and trapped 4-OHCP to be simultaneously measured by use of tandem mass spectrometry. Pharmacokinetic parameters were determined from drug concentration-versus-time data for both cyclophosphamide and 4-OHCP. RESULTS Cyclophosphamide was tolerated well regardless of route of administration. Pharmacokinetic parameters for 4-OHCP were similar after oral, IV, and IP administration. Area under the concentration-time curve for cyclophosphamide was lower after oral administration than after IV or IP administration. CONCLUSIONS AND CLINICAL RELEVANCE Cyclophosphamide can be administered interchangeably to cats as oral, IV, and IP formulations, which should provide benefits with regard to cost and ease of administration to certain feline patients.
- Subjects :
- Male
Drug
Cyclophosphamide
040301 veterinary sciences
media_common.quotation_subject
Administration, Oral
Biological Availability
Pharmacology
Article
0403 veterinary science
03 medical and health sciences
Route of administration
0302 clinical medicine
Pharmacokinetics
Tandem Mass Spectrometry
Oral administration
Animals
Medicine
Antineoplastic Agents, Alkylating
media_common
CATS
General Veterinary
business.industry
4-Hydroxycyclophosphamide
Half-life
04 agricultural and veterinary sciences
General Medicine
Area Under Curve
030220 oncology & carcinogenesis
Anesthesia
Cats
Administration, Intravenous
Female
business
Injections, Intraperitoneal
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 00029645
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- American Journal of Veterinary Research
- Accession number :
- edsair.doi.dedup.....7c75d00719cf2927e6d476fa5f71f20e