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Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks
Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks
- Source :
- Clinical and Experimental Gastroenterology
- Publication Year :
- 2021
-
Abstract
- Nonalcoholic fatty liver disease and chronic kidney disease are both chronic conditions with rapidly increasing prevalence and incidence worldwide that have led to a significant burden on health-care systems. The association between these two disease entities is partly attributed to shared cardiometabolic comorbidities including diabetes, hypertension, obesity, and metabolic syndrome. However, independent of these overlapping risks, there are increased rates and more severe CKD in NAFLD patients. Conversely, more progressive NAFLD is seen with advanced stages of kidney injury. In addition to overlapping risk factors, shared pathogenic mechanisms suggest these two disease entities may resemble different manifestations of a single underlying disease process.
- Subjects :
- nonalcoholic fatty liver disease
medicine.medical_specialty
gut-liver axis
liver-kidney axis
business.industry
Incidence (epidemiology)
Advanced stage
Gastroenterology
Disease
Review
medicine.disease
Obesity
mortality
metabolic syndrome
gut-kidney axis
Internal medicine
Diabetes mellitus
Nonalcoholic fatty liver disease
Medicine
Metabolic syndrome
business
chronic kidney disease
Kidney disease
Subjects
Details
- ISSN :
- 11787023
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental gastroenterology
- Accession number :
- edsair.doi.dedup.....7c759d085fd63c45a90e817ea9586b85