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Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks

Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: A Review of Links and Risks

Authors :
Amanda Cheung
Aijaz Ahmed
Source :
Clinical and Experimental Gastroenterology
Publication Year :
2021

Abstract

Nonalcoholic fatty liver disease and chronic kidney disease are both chronic conditions with rapidly increasing prevalence and incidence worldwide that have led to a significant burden on health-care systems. The association between these two disease entities is partly attributed to shared cardiometabolic comorbidities including diabetes, hypertension, obesity, and metabolic syndrome. However, independent of these overlapping risks, there are increased rates and more severe CKD in NAFLD patients. Conversely, more progressive NAFLD is seen with advanced stages of kidney injury. In addition to overlapping risk factors, shared pathogenic mechanisms suggest these two disease entities may resemble different manifestations of a single underlying disease process.

Details

ISSN :
11787023
Volume :
14
Database :
OpenAIRE
Journal :
Clinical and experimental gastroenterology
Accession number :
edsair.doi.dedup.....7c759d085fd63c45a90e817ea9586b85