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The role of thymic stromal lymphopoietin in the development of chronic otitis media with effusion
- Source :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 279(4)
- Publication Year :
- 2021
-
Abstract
- To investigate the effect of thymic stromal lymphopoietin on the development of chronic otitis media with effusion MATERIALS AND METHODS: This study was conducted on 40 patients who had adenoidectomy operation. The objects were divided into two groups. Group 1; adenoidectomy with chronic serous otitis media, group 2; adenoidectomy without chronic serous otitis media. Serum and tissue thymic stromal lymphopoietin levels were measured by ELISA. Serum and tissue TLSP levels, mast cell count, adenoid size were compared between the groups.Twenty-four (60%) of patients were female and 16 (40%) were male. Twenty patients (55%) had adenoid hypertrophy with chronic serous otitis media, and 18 (45%) had adenoid hypertrophy without chronic serous otitis media. The mean age of the patients was 6.21 ± 2.31 years. The mean mast cell count was significantly higher in group 1 compared with group 2 (p = 0.017). The mean tissue thymic stromal lymphopoietin measurement was also significantly higher in group 1 than group 2 (p = 0.023). However, there was no significant difference in regards to serum levels between the groups (p = 0.480).The number of mast cells as well as thymic stromal lymphopoietin levels in the adenoids of children was significantly high in the chronic serous otitis media patients. The release of thymic stromal lymphopoietin from the adenoid tissue plays a role in initiating and maintaining a local inflammatory reaction in the eustachian tube that may lead eventually to middle ear effusion in non-atopic patients.
- Subjects :
- Male
medicine.medical_specialty
Thymic stromal lymphopoietin
Eustachian tube
medicine.medical_treatment
Chronic otitis
Adenoid
Gastroenterology
Adenoidectomy
Thymic Stromal Lymphopoietin
Internal medicine
medicine
Humans
Child
business.industry
Otitis Media with Effusion
General Medicine
Hypertrophy
medicine.disease
Middle ear effusion
Otitis Media
medicine.anatomical_structure
Otorhinolaryngology
Effusion
Child, Preschool
Adenoids
Cytokines
Female
business
Adenoid hypertrophy
Subjects
Details
- ISSN :
- 14344726
- Volume :
- 279
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....7c6fe4ae54e915479fb87cbc1604b7bb