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Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria

Authors :
Rosa Gouveia
Stanley J. Radio
Marc K. Halushka
Angela Pucci
Ivana Kholová
Gaetano Thiene
Richard N. Mitchell
Dylan V. Miller
Allard C. van der Wal
Silvio H. Litovsky
Jagdish Butany
Patrick J. Gallagher
Mary N. Sheppard
Stephen D. Preston
E. Rene Rodriguez
Giovanni Bartoloni
Joseph J. Maleszewski
S. Kim Suvarna
Ornella Leone
Giulia d'Amati
Adriana C. Gittenberger-de Groot
James R. Stone
Patrick Bruneval
Cristina Basso
Annalisa Angelini
John T. Fallon
Lubov Batoroeva
L. Maximilian Buja
John P. Veinot
Karen L. Kelly
Carmela D. Tan
Source :
Cardiovascular Pathology, 25(3), 247-257
Publication Year :
2016

Abstract

Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. A number of diseases, genetic syndromes (Marfan syndrome, Loeys–Dietz syndrome, etc.), and vasculopathic aging processes involved in vascular injury can cause both distinct and nonspecific histopathologic changes with degeneration of the media as a common denominator. Terminology for these changes has varied over time leading to confusion and inconsistencies. This consensus document has established a revised, unified nomenclature for the variety of noninflammatory degenerative aortic histopathologies seen in such specimens. Older terms such as cystic medial necrosis and medionecrosis are replaced by more technically accurate terms such as mucoid extracellular matrix accumulation (MEMA), elastic fiber fragmentation and/or loss, and smooth muscle cell nuclei loss. A straightforward system of grading is presented to gauge the extent of medial degeneration and synoptic reporting tables are provided. Herein we present a standardized nomenclature that is accessible to general pathologists and useful for future publications describing these entities.

Details

Language :
English
Database :
OpenAIRE
Journal :
Cardiovascular Pathology, 25(3), 247-257
Accession number :
edsair.doi.dedup.....7c669f1e15142b431b67aa22211ebb20