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Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria
- Source :
- Cardiovascular Pathology, 25(3), 247-257
- Publication Year :
- 2016
-
Abstract
- Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. A number of diseases, genetic syndromes (Marfan syndrome, Loeys–Dietz syndrome, etc.), and vasculopathic aging processes involved in vascular injury can cause both distinct and nonspecific histopathologic changes with degeneration of the media as a common denominator. Terminology for these changes has varied over time leading to confusion and inconsistencies. This consensus document has established a revised, unified nomenclature for the variety of noninflammatory degenerative aortic histopathologies seen in such specimens. Older terms such as cystic medial necrosis and medionecrosis are replaced by more technically accurate terms such as mucoid extracellular matrix accumulation (MEMA), elastic fiber fragmentation and/or loss, and smooth muscle cell nuclei loss. A straightforward system of grading is presented to gauge the extent of medial degeneration and synoptic reporting tables are provided. Herein we present a standardized nomenclature that is accessible to general pathologists and useful for future publications describing these entities.
- Subjects :
- 0301 basic medicine
Marfan syndrome
Pathology
medicine.medical_specialty
Loeys–Dietz syndrome
Bicuspid aortic valve
Pathology, Surgical
Aortic Diseases
Cardiology
Histopathology
030204 cardiovascular system & hematology
Pathology and Forensic Medicine
Surgical pathology
03 medical and health sciences
0302 clinical medicine
Aneurysm
Terminology as Topic
medicine.artery
medicine
Humans
Consensus document
Aorta
Cystic medial degeneration
Degenerative
Dissection
Lamellar unit
Medial degeneration
Noninflammatory
Grading (tumors)
aneurysm
aorta
bicuspid aortic valve
consensus document
cystic medial degeneration
degenerative
dissection
histopathology
lamellar unit
Loeys-Dietz syndrome
medial degeneration
noninflammatory
cardiology and cardiovascular medicine
business.industry
General Medicine
medicine.disease
030104 developmental biology
business
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Pathology, 25(3), 247-257
- Accession number :
- edsair.doi.dedup.....7c669f1e15142b431b67aa22211ebb20