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Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas
- Source :
- Cancer Cell. (3):215-229
- Publisher :
- Elsevier Inc.
-
Abstract
- SummaryNoncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. We report that a large fraction of genomic ultraconserved regions (UCRs) encode a particular set of ncRNAs whose expression is altered in human cancers. Genome-wide profiling revealed that UCRs have distinct signatures in human leukemias and carcinomas. UCRs are frequently located at fragile sites and genomic regions involved in cancers. We identified certain UCRs whose expression may be regulated by microRNAs abnormally expressed in human chronic lymphocytic leukemia, and we proved that the inhibition of an overexpressed UCR induces apoptosis in colon cancer cells. Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought.
- Subjects :
- EXPRESSION
Cancer Research
RNA, Untranslated
Molecular Sequence Data
CELLCYCLE
Biology
medicine.disease_cause
HUMAN CANCERS
microRNA
medicine
HUMAN GENOME
Cluster Analysis
Humans
Gene
SIGNATURES
Conserved Sequence
Genetics
Regulation of gene expression
Leukemia
IDENTIFICATION
Base Sequence
CHRONIC LYMPHOCYTIC-LEUKEMIA
Sequence Analysis, RNA
Gene Expression Profiling
Chromosomal fragile site
Carcinoma
Oncogenes
Cell Biology
HUMAN MICRORNA GENES
NONCODING SEQUENCES
Non-coding RNA
Gene Expression Regulation, Neoplastic
Gene expression profiling
MicroRNAs
Oncology
B-CELL LYMPHOMAS
RNA
Human genome
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cancer Cell
- Accession number :
- edsair.doi.dedup.....7c57f937bdc1ef7b145b16d912612eae
- Full Text :
- https://doi.org/10.1016/j.ccr.2007.07.027