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High levels of HB-EGF and interleukin-18 are associated with a high risk of in-stent restenosis
- Source :
- Anatolian Journal of Cardiology
- Publication Year :
- 2015
- Publisher :
- Kare Publishing, 2015.
-
Abstract
- Objective: To explore the clinical significance of heparin-binding epidermal growth factor-like growth factor (HB-EGF), interleukin-18 (IL-18), and interleukin-10 (IL-10) in restenosis after percutaneous coronary intervention (PCI). Methods: A total of 198 patients with acute coronary syndrome underwent coronary drug-eluting stent implantation and were divided into the restenosis group and non-restenosis group on the basis of second coronary angiography. Biological parameters and HB-EGF, IL-18, and IL-10 levels were measured. Patients in the restenosis group were further divided into 3 subgroups according to Gensini score: group A (Gensini score of 20 but 40). Results: Compared with the non-restenosis group, HB-EGF and IL-18 levels were significantly higher but serum IL-10 levels were significantly lower in the restenosis group. Furthermore, HB-EGF levels increased with the Gensini score among the 3 subgroups. Spearman’s correlation analysis showed that HB-EGF levels were associated with IL-18 levels and the number of diseased vessels. Multivariate logistic regression analysis showed that diabetes, HB-EGF, and IL-18 were risk factors for restenosis [odds ratio with 95% confidence interval: 3.902 (1.188-4.415), 2.185 (1.103-4.014), and 2.079 (1.208-4.027), respectively]. Conclusion: The present study has demonstrated that HB-EGF may be used to evaluate the severity of restenosis and coronary artery lesion and that inflammatory responses may be involved in the process of restenosis.
- Subjects :
- medicine.medical_specialty
Acute coronary syndrome
coronary artery
business.industry
medicine.medical_treatment
Percutaneous coronary intervention
Odds ratio
medicine.disease
Confidence interval
HB-EGF
restenosis
Restenosis
Internal medicine
Diabetes mellitus
Conventional PCI
IL-10
medicine
Cardiology
Clinical significance
Cardiology and Cardiovascular Medicine
business
IL-18
Original Investigation
Subjects
Details
- Language :
- English
- ISSN :
- 21492271 and 21492263
- Volume :
- 15
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Anatolian Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....7c535293b4450406fd1447196f386025