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Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin
- Source :
- Chemical communications (Cambridge, England). 58(39)
- Publication Year :
- 2022
-
Abstract
- An artificial disulfide bond (Cys46-Cys61) was designed in the heme distal site of myoglobin, which regulates the conformation of the heme distal His64 and the protein reactivity, as confirmed by X-ray crystallography, EPR, and kinetic UV-vis studies. This study shows the successful design of a disulfide bond with suitable positions in globins, conferring a structure and function like those of the native human neuroglobin.
Details
- ISSN :
- 1364548X
- Volume :
- 58
- Issue :
- 39
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....7c511032398ba3a71fa0677ca00d5a8d