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GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle
- Source :
- NeuroReport, NeuroReport, 2005, 16 (10), pp.1069-1073. ⟨10.1097/00001756-200507130-00008⟩, NeuroReport, Lippincott, Williams & Wilkins, 2005, 16 (10), pp.1069-1073. ⟨10.1097/00001756-200507130-00008⟩
- Publication Year :
- 2005
- Publisher :
- HAL CCSD, 2005.
-
Abstract
- International audience; The perifornical-lateral hypothalamic area is implicated in regulating waking and paradoxical sleep. The blockade of GABAA receptors by iontophoretic applications of bicuculline (or gabazine) into the perifornical-lateral hypothalamic area induced a continuous quiet waking state associated to a robust muscle tone in head-restrained rats. During the effects, sleep was totally suppressed. In rats killed at the end of a 90 min ejection of bicuculline, Fos expression was induced in approximately 28% of the neurons immunoreactive for hypocretin and in approximately 3% of the neurons immunostained for melanin-concentrating hormone within the ejection site. These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation.
- Subjects :
- Male
Melanin-concentrating hormone
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
MESH: Neurons
MESH: Rats, Sprague-Dawley
MESH: GABA Antagonists
GABA Antagonists
Rats, Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
MESH: Melanins
MESH: Animals
MESH: GABA-A Receptor Antagonists
MESH: Receptors, GABA-A
ComputingMilieux_MISCELLANEOUS
Neurons
0303 health sciences
Hypothalamic Hormones
GABAA receptor
General Neuroscience
Electroencephalography
medicine.anatomical_structure
MESH: Pituitary Hormones
Hypothalamus
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Sleep Stages
psychological phenomena and processes
medicine.drug
medicine.medical_specialty
MESH: Rats
Rapid eye movement sleep
Biology
03 medical and health sciences
Internal medicine
MESH: Electroencephalography
medicine
Animals
GABA-A Receptor Antagonists
Wakefulness
030304 developmental biology
Melanins
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Bicuculline
MESH: Sleep Stages
Receptors, GABA-A
MESH: Hypothalamus
MESH: Male
Orexin
Rats
MESH: Hypothalamic Hormones
Pituitary Hormones
MESH: Wakefulness
Endocrinology
chemistry
Gabazine
Neuron
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 09594965
- Database :
- OpenAIRE
- Journal :
- NeuroReport, NeuroReport, 2005, 16 (10), pp.1069-1073. ⟨10.1097/00001756-200507130-00008⟩, NeuroReport, Lippincott, Williams & Wilkins, 2005, 16 (10), pp.1069-1073. ⟨10.1097/00001756-200507130-00008⟩
- Accession number :
- edsair.doi.dedup.....7c4db03cdafcbad4b670e400b7817c02