Back to Search
Start Over
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
- Source :
- Cytokine & Growth Factor Reviews. 17:349-366
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Ralpha and IL-2Rbeta, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. gamma(c), which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area-the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge.
- Subjects :
- Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Immunology
Biology
General Biochemistry, Genetics and Molecular Biology
Cyclic AMP Response Element Modulator
Mice
STAT5 Transcription Factor
medicine
Animals
Humans
Immunology and Allergy
IL-2 receptor
RNA Processing, Post-Transcriptional
Cyclic AMP Response Element-Binding Protein
Receptor
Common gamma chain
Genetics
Regulation of gene expression
NFATC Transcription Factors
Growth factor
Interleukin-2 Receptor alpha Subunit
NF-kappa B
Receptors, Interleukin-2
Phenotype
Cell biology
Interleukin-2 Receptor beta Subunit
Transcription Factor AP-1
Cytokine
Gene Expression Regulation
Interleukin-21 receptor
Interleukin-2
Subjects
Details
- ISSN :
- 13596101
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cytokine & Growth Factor Reviews
- Accession number :
- edsair.doi.dedup.....7c43a06d6534aac0a6d790fabac8e5a6