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Characterization of T cell immunity in chronic hepatitis B virus-infected mothers with postpartum alanine transaminase flare
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
-
Abstract
- Background Postpartum alanine transaminase (ALT) flares occur frequently in chronic hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT). We aimed to characterize the T cell immunity in HBV-infected mothers experiencing postpartum ALT flares. Methods Twenty HBV-infected pregnant women who received AVT at 26–28 weeks of gestation were enrolled and followed up until 15–18 weeks postpartum. Among the 20 HBV-infected pregnant women, 6 experienced postpartum ALT flare (AF mothers), while 14 did not (NAF mothers). T lymphocyte phenotypes and functions were analyzed using flow cytometry. Results Compared to NAF mothers, the quantitative HBsAg levels in AF mothers decreased significantly at 6–8 or 15–18 weeks postpartum. Significant differences in HBeAg levels between these groups were only found at delivery. Regulatory T cell (Treg) numbers in AF mothers were lower than those of NAF mothers before AVT; however, there were no significant differences in Treg numbers at other follow-up points. Expression of other T cell phenotypes were similar between the two groups. T cells in AF mothers produced more pro-inflammatory cytokines (IFN-γ, IL-21, TNF-α, IL-2) or less anti-inflammatory cytokine (IL-10) than those in NAF mothers before, during, or after antiviral treatment. The ratio of IFN-γ to IL-10 producing by CD4+ T cells or CD8+ T cells was higher in AF mothers than that in NAF mothers during pregnancy or after delivery. Conclusions The characteristics of T cell immunity was distinct between mothers with postpartum ALT flare and those without ALT flare from pregnancy to postpartum, which indicated that T cell immunity might get involved in postpartum ALT flare.
- Subjects :
- Hepatitis B virus
Regulatory T cell
T cell
Physiology
Mothers
Infectious and parasitic diseases
RC109-216
CD8-Positive T-Lymphocytes
medicine.disease_cause
Antiviral Agents
Alanine transaminase flare
Hepatitis B, Chronic
Pregnancy
Postpartum
Medicine
Humans
Hepatitis B e Antigens
biology
T cell immunity
business.industry
Research
Postpartum Period
Alanine Transaminase
medicine.disease
digestive system diseases
Infectious Diseases
medicine.anatomical_structure
Alanine transaminase
HBeAg
DNA, Viral
biology.protein
Gestation
Female
business
CD8
Subjects
Details
- ISSN :
- 14712334
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC infectious diseases
- Accession number :
- edsair.doi.dedup.....7c393a740d1aae291cbb6ceb5090f8c6