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Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells

Authors :
Kazuhiko R. Utsumi
Masumi Abe
Michihiro Shamoto
Hiroshi Shiku
Yoshikazu Kurosawa
Kazumasa Yamada
Koji Kato
Katsuo Koie
Koichi Koike
Tomoki Naoe
Yukihiro Akao
Source :
Cancer genetics and cytogenetics. 34(1)
Publication Year :
1988

Abstract

A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q−, 6q−, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.

Details

ISSN :
01654608
Volume :
34
Issue :
1
Database :
OpenAIRE
Journal :
Cancer genetics and cytogenetics
Accession number :
edsair.doi.dedup.....7c354d077200ab0da430cb156da565d1