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Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells
- Source :
- Cancer genetics and cytogenetics. 34(1)
- Publication Year :
- 1988
-
Abstract
- A T-cell line, ATN-1, was established by culturing peripheral blood mononuclear cells derived from a patient with adult T-cell leukemia/lymphoma (ATL/L). Identities of the patterns of chromosomal abnormalities, cell surface phenotypes, morphologic findings, rearrangement patterns of T-cell receptor β chain gene, and an integration site of human T-cell leukemia virus I proviral genome indicated that ATN-1 was derived from original leukemic cells. Both ATN-1 and the original leukemic cells showed a variety of patterns of chromosomal abnormalities that include 3q−, 6q−, rearrangements involving 2q31, 7q11.2, 8q11, 8q24, 19p13.3, and also 14q11 and 14q32, where genes for the T-cell receptor α chain and the immunoglobulin heavy chain are located. Availability of a genuine ATL/L cell line with these chromosomal abnormalities may greatly facilitate the biologic analysis of ATL/L.
- Subjects :
- Male
Cancer Research
T cell
T-Lymphocytes
T-cell leukemia
Chromosome Disorders
Peripheral blood mononuclear cell
Cell Line
hemic and lymphatic diseases
Genetics
medicine
Humans
Molecular Biology
Chromosome Aberrations
Leukemia
biology
Antibodies, Monoclonal
Nucleic Acid Hybridization
Gene rearrangement
DNA, Neoplasm
Middle Aged
medicine.disease
Virology
Molecular biology
medicine.anatomical_structure
Cell culture
Karyotyping
Antigens, Surface
biology.protein
Immunoglobulin heavy chain
Antibody
Subjects
Details
- ISSN :
- 01654608
- Volume :
- 34
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer genetics and cytogenetics
- Accession number :
- edsair.doi.dedup.....7c354d077200ab0da430cb156da565d1