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Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study
- Source :
- Johansen, J, Buus, S, Loft, A, Keiding, S, Overgaard, M, Hansen, H S, Grau, C, Bundgaard, T, Kirkegaard, J & Overgaard, J 2008, ' Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study ', Head & Neck (Print Edition), vol. 30, no. 4, pp. 471-8 . https://doi.org/10.1002/hed.20734, Johansen, J, Buus, S, Loft, A, Keiding, S, Overgaard, M, Hansen, H S, Grau, C, Bundgaard, T, Kirkegaard, J & Overgaard, J 2008, ' Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study ', Head & Neck (Print Edition), vol. 30, no. 4, pp. 471-478 . https://doi.org/10.1002/hed.20734
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- BACKGROUND.: The benefit of a complementary fluorodeoxyglucose-positron emission tomography (FDG-PET) scan to standard workup for carcinoma of unknown primary (CUP) and metastatic neck lesions was prospectively studied. METHODS.: Sixty-seven patients underwent standardized diagnostic workup according to national guidelines including panendoscopies, multiple mucosal biopsies, and diagnostic CT/MRI scans. Median follow-up was 40 months (range, 2-65 months). RESULTS.: In 60 eligible patients, FDG-PET indicated a primary tumor or metastatic disease in 30 patients (50%). Additional investigations confirmed a primary tumor in 18 patients: hypopharynx in 5, oropharynx in 5, nasopharynx in 2, lung in 1, axilla in 1, bone in 1, rectum in 1, as well as multiple metastatic lesions from CUP in 2 patients. In retrospect, MRI was able to detect 1 of the PET-detected primaries, leading to an overall detection rate of PET of 29% in CUP. A therapeutic change of treatment was made in 25% as a consequence of FDG-PET. PET before panendoscopy demonstrated fewer false-positive pathological foci. CONCLUSION.: FDG-PET is a valuable tool in addition to conventional extensive workup in CUP and neck metastases. Consequently, FDG-PET is now recommended as an early diagnostic modality in the workup of these patients. (c) 2007 Wiley Periodicals, Inc. Head Neck, 2007.
- Subjects :
- Adult
Male
medicine.medical_treatment
Sensitivity and Specificity
Fluorodeoxyglucose F18
Predictive Value of Tests
Neoplasms
Carcinoma
Humans
Medicine
Prospective Studies
Prospective cohort study
Lymph node
Aged
medicine.diagnostic_test
business.industry
Head and neck cancer
Endoscopy
Neck dissection
Middle Aged
medicine.disease
Radiation therapy
DAHANCA
medicine.anatomical_structure
Otorhinolaryngology
Positron emission tomography
Lymphatic Metastasis
Positron-Emission Tomography
Practice Guidelines as Topic
cardiovascular system
Neck Dissection
Neoplasms, Unknown Primary
Female
Radiotherapy, Adjuvant
Radiopharmaceuticals
business
Nuclear medicine
Follow-Up Studies
Subjects
Details
- ISSN :
- 10970347 and 10433074
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....7c3502900365c0d5a3abf7fdeda75a9b