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PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma–paraganglioma origin
- Source :
- Apmis
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Neuroendocrine tumors (NETs) are often diagnosed from the metastases of an unknown primary tumor. Specific immunohistochemical (IHC) markers indicating the location of a primary tumor are needed. The proprotein convertase subtilisin/kexin type 2 (PCSK2) is found in normal neural and neuroendocrine cells, and known to express in NETs. We investigated the tissue microarray (TMA) of 86 primary tumors from 13 different organs and 9 metastatic NETs, including primary tumor-metastasis pairs, for PCSK2 expression with polymer-based IHC. PCSK2 was strongly positive in all small intestine and appendiceal NETs, the so-called midgut NETs, in most pheochromocytomas and paragangliomas, and in some of the typical and atypical pulmonary carcinoid tumors. NETs showing strong positivity were re-evaluated in larger tumor cohorts confirming the primary observation. In the metastases, the expression of PCSK2 mirrored that of the corresponding primary tumors. We found negative or weak staining in NETs from the thymus, gastric mucosa, pancreas, rectum, thyroid, and parathyroid. PCSK2 expression did not correlate with Ki-67 in well-differentiated NETs. Our data suggest that PCSK2 positivity can indicate the location of the primary tumor. Thus, PCSK2 could function in the IHC panel determined from screening metastatic NET biopsies of unknown primary origins.
- Subjects :
- Male
Pathology
Lung Neoplasms
Adrenal Gland Neoplasms
Gene Expression
Neuroendocrine tumors
CHROMOGRANIN-A
CONVERTASE-2
PC2
0302 clinical medicine
MARKERS
Paraganglioma
Immunology and Allergy
Gastrointestinal Neoplasms
11832 Microbiology and virology
0303 health sciences
Tissue microarray
biology
Chromogranin A
General Medicine
Primary tumor
PROTEIN 7B2
3. Good health
Proprotein Convertase 2
Lymphatic Metastasis
030220 oncology & carcinogenesis
immunohistochemistry
Immunohistochemistry
Female
Original Article
STANDARDS
Microbiology (medical)
medicine.medical_specialty
Carcinoid tumors
Pheochromocytoma
Adenocarcinoma
HUMAN TISSUES
Pathology and Forensic Medicine
03 medical and health sciences
Biomarkers, Tumor
medicine
Humans
primary origin
Thyroid Neoplasms
Neoplasm Staging
030304 developmental biology
MEDICINE
business.industry
Original Articles
PCSK2
medicine.disease
Carcinoma, Neuroendocrine
Ki-67 Antigen
CELLS
biology.protein
3111 Biomedicine
business
Subjects
Details
- ISSN :
- 16000463 and 09034641
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- APMIS
- Accession number :
- edsair.doi.dedup.....7c240dc738b5b4fb6cc232f90e8537a6