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Variation analysis of EXO1 gene in Chinese patients with premature ovarian failure
- Source :
- Reproductive biomedicine online. 32(3)
- Publication Year :
- 2015
-
Abstract
- Exonuclease 1 (EXO1) is required for both DNA repair and meiosis. Inactivation of EXO1 gene in mice leads to infertility. This study aimed to investigate whether variants in the EXO1 gene contribute to human premature ovarian failure (POF). The coding region of EXO1 was sequenced in 186 Han Chinese patients with non-syndromic POF. No plausible mutation was detected. The results suggest that mutations in the coding region of EXO1 may not be responsible for POF in Han Chinese women.
- Subjects :
- 0301 basic medicine
Infertility
Adult
China
endocrine system diseases
Genotype
DNA repair
DNA Mutational Analysis
Single-nucleotide polymorphism
Biology
Primary Ovarian Insufficiency
Bioinformatics
medicine.disease_cause
Polymorphism, Single Nucleotide
03 medical and health sciences
Exonuclease 1
Asian People
Gene Frequency
medicine
Coding region
Humans
Gene
Genetics
Mutation
Obstetrics and Gynecology
medicine.disease
female genital diseases and pregnancy complications
Premature ovarian failure
030104 developmental biology
DNA Repair Enzymes
Exodeoxyribonucleases
Reproductive Medicine
Female
Developmental Biology
Subjects
Details
- ISSN :
- 14726491
- Volume :
- 32
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Reproductive biomedicine online
- Accession number :
- edsair.doi.dedup.....7c1eba12477c597700620bbd3b7c9bff