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Emergence of Morganellaceae Harboring bla IMP-27 Metalloenzyme in Canada
- Source :
- mSphere, Vol 6, Iss 3 (2021)
- Publication Year :
- 2021
- Publisher :
- American Society for Microbiology, 2021.
-
Abstract
- In 2018 to 2019, PCR for carbapenemases in routine Gram-negative isolates submitted to the National Microbiology Laboratory revealed an increase in IMP-type metalloenzyme-positive isolates, mostly among Morganellaceae Whole-genome sequencing revealed that 23 Morganellaceae harbored blaIMP-27 within a chromosomal Tn7 element. Phylogenomics indicated diversity of isolates but also the presence of a few clonal isolates dispersed geographically. These isolates may be difficult to detect due to carbapenem susceptibility and false-negative results in phenotypic testing.IMPORTANCE Over the last decade or so, the frequency of isolation of clinical carbapenemase-producing organisms (CPOs) has increased among health care-associated infections. This may seriously compromise antimicrobial therapy, as carbapenems are considered the last line of defense against these organisms. The ability of carbapenemases to hydrolyze most β-lactams in addition to the co-occurrence of mechanisms of resistance to other classes of antimicrobials in CPOs can leave few options for treating infections. The class B metalloenzymes are globally distributed carbapenemases, and the most commonly found include the NDM, VIM, and IMP types. Our study describes a sudden emergence of IMP-27-harboring Morganellaceae during 2018 to 2019 in Canada. There is a paucity of literature on IMP-27 isolates, and our data bolster the information on the genetic context, antimicrobial profiles, and phylogenomics of this group of CPOs.
- Subjects :
- Genetics
0303 health sciences
Carbapenem
030306 microbiology
Context (language use)
Biology
Isolation (microbiology)
Antimicrobial
Microbiology
QR1-502
03 medical and health sciences
Antibiotic resistance
Phylogenomics
medicine
Molecular Biology
Morganellaceae
030304 developmental biology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23795042
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- mSphere
- Accession number :
- edsair.doi.dedup.....7c13bbc6d2a4bc9b9b25fb2332bfa312