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Effects of ezrin knockdown on the structure of gastric glandular epithelia
- Source :
- The journal of physiological sciences : JPS. 66(1)
- Publication Year :
- 2015
-
Abstract
- Ezrin, an adaptor protein that cross-links plasma membrane-associated proteins with the actin cytoskeleton, is concentrated on apical surfaces of epithelial cells, especially in microvilli of the small intestine and stomach. In the stomach, ezrin is predominantly expressed on the apical canalicular membrane of parietal cells. Transgenic ezrin knockdown mice in which the expression level of ezrin was reduced to
- Subjects :
- 0301 basic medicine
Physiology
Muscle Proteins
Mice, Transgenic
macromolecular substances
Biology
Achlorhydria
Antibodies
Epithelium
03 medical and health sciences
Mice
Ezrin
Parietal Cells, Gastric
Gastric glands
Lectins
Gastrins
medicine
Animals
Mucin-6
Stomach
digestive, oral, and skin physiology
Mucins
Actin cytoskeleton
medicine.disease
Cell biology
Up-Regulation
Gastric chief cell
Foveolar cell
Cytoskeletal Proteins
030104 developmental biology
medicine.anatomical_structure
Biochemistry
Gene Expression Regulation
Microscopy, Fluorescence
Gastric Mucosa
Gene Knockdown Techniques
RNA
Trefoil Factor-2
Peptides
Subjects
Details
- ISSN :
- 18806562
- Volume :
- 66
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The journal of physiological sciences : JPS
- Accession number :
- edsair.doi.dedup.....7c09e97e34275a2e3cf88116fedc8860