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Cdc25A and Dub3 in a high-stakes balancing act
- Source :
- Nature cell biology. 12(4)
- Publication Year :
- 2010
-
Abstract
- The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.
- Subjects :
- CDC25A
Proteasome Endopeptidase Complex
Phosphatase
Regulator
Genes, myc
Apoptosis
Breast Neoplasms
Biology
Ubiquitin
Endopeptidases
Enzyme Stability
CDC25A Protein
Animals
Humans
cdc25 Phosphatases
Cell Proliferation
Regulation of gene expression
Deubiquitylating enzyme
Cell Cycle
Ubiquitination
Cell Biology
humanities
Cell biology
Gene Expression Regulation, Neoplastic
Cell Transformation, Neoplastic
Genes, ras
Post translational
Cancer research
biology.protein
Female
Protein Processing, Post-Translational
DNA Damage
Subjects
Details
- ISSN :
- 14764679
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nature cell biology
- Accession number :
- edsair.doi.dedup.....7c07cc6233a89f0b813107bc4bb39729