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MicroRNAs in Tumor Cell Metabolism: Roles and Therapeutic Opportunities
- Source :
- Frontiers in Oncology, Vol 9 (2019), Frontiers in Oncology
- Publication Year :
- 2019
- Publisher :
- Frontiers Media S.A., 2019.
-
Abstract
- Dysregulated metabolism is a common feature of cancer cells and is considered a hallmark of cancer. Altered tumor-metabolism confers an adaptive advantage to cancer cells to fulfill the high energetic requirements for the maintenance of high proliferation rates, similarly, reprogramming metabolism confers the ability to grow at low oxygen concentrations and to use alternative carbon sources. These phenomena result from the dysregulated expression of diverse genes, including those encoding microRNAs (miRNAs) which are involved in several metabolic and tumorigenic pathways through its post-transcriptional-regulatory activity. Further, the identification of key actionable altered miRNA has allowed to propose novel targeted therapies to modulated tumor-metabolism. In this review, we discussed the different roles of miRNAs in cancer cell metabolism and novel miRNA-based strategies designed to target the metabolic machinery in human cancer.
- Subjects :
- 0301 basic medicine
Cancer Research
Tumor cells
Review
Computational biology
Biology
therapeutic targets
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
microRNA
medicine
tumor cell metabolism
Gene
Low oxygen
Cancer
regulation
Metabolism
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
reprogramming metabolism
microRNAs
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer cell
Reprogramming
Subjects
Details
- Language :
- English
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in Oncology
- Accession number :
- edsair.doi.dedup.....7beac1fea7e6613df867cdcdec5d04c7