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Cephalosporin Induced Toxic Epidermal Necrolysis and Subsequent Penicillin Drug Exanthem
- Source :
- Allergology International, Vol 57, Iss 3, Pp 281-284 (2008)
- Publisher :
- Japanese Society of Allergology. Production and hosting by Elsevier B.V.
-
Abstract
- Background Drug hypersensitivity is classically divided into IgE mediated and non-IgE mediated disease. We report a rare case of consequent IgE mediated and non-IgE mediated reactions within the beta lactam class of antibiotics. Case Summary An 84-year-old man developed toxic epidermal necrolysis (TEN) due to ceftriaxone, a third generation cephalosporin, involving 72% of the body surface area. The patient recovered but within weeks subsequently developed an acute IgE mediated allergic reaction to piperacillin/tazobactam, an extended spectrum penicillin. Further IgE RAST revealed positive results to penicillin major determinant. Discussion This case demonstrates the complexity of drug hypersensitivity reactions. While it is accepted that IgE mediated penicillin allergy is a predisposition to cephalosporin allergy, this case displays an unusual correlation between drug hypersensitivity and drug class. There have been few studies that evaluate the cross reactivity with penicillin or other beta-lactams in subjects with primary hypersensitivity to cephalosporins. This clinical scenario emphasizes the need of more studies on cephalosporin allergy in particular as shown by this case of sequential non-IgE mediated cephalosporin induced TEN reaction pursuant by an IgE mediated penicillin allergy.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Male
medicine.drug_class
Cephalosporin
Antibiotics
cephalosporin
Penicillanic Acid
Immunoglobulin E
Tazobactam
Microbiology
Drug Hypersensitivity
toxic epidernal necrolysis
medicine
polycyclic compounds
Humans
Immunology and Allergy
Aged, 80 and over
Piperacillin
biology
business.industry
beta-lactams
General Medicine
Exanthema
medicine.disease
Toxic epidermal necrolysis
Cephalosporins
Penicillin
Piperacillin, Tazobactam Drug Combination
penicillin
Stevens-Johnson Syndrome
Immunology
biology.protein
Ceftriaxone
lcsh:RC581-607
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13238930
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Allergology International
- Accession number :
- edsair.doi.dedup.....7be93a0914be9a36c19e8af869776187
- Full Text :
- https://doi.org/10.2332/allergolint.C-07-55