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Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
- Source :
- Nature Genetics, 51, 394-403. Nature Publishing Group, Nature genetics, 51(3), 394-403. Nature Publishing Group, Nature Genetics, 51, 394. Nature Publishing Group, Nature Genetics, 51(3), 394-403. Nature Publishing Group, Nature Genetics, The 23andMe Research Team 2019, ' Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways ', Nature Genetics, vol. 51, no. 3, pp. 394-403 . https://doi.org/10.1038/s41588-018-0333-3, the 23andMe Research Team 2019, ' Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways ', Nature Genetics, vol. 51, no. 3, pp. 394-403 . https://doi.org/10.1038/s41588-018-0333-3
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. Here, we use a large genetic association sample (n = 1,331,010) to detect novel loci and gain insight into the pathways, tissue and cell types involved in insomnia complaints. We identify 202 loci implicating 956 genes through positional, expression quantitative trait loci, and chromatin mapping. The meta-analysis explained 2.6% of the variance. We show gene set enrichments for the axonal part of neurons, cortical and subcortical tissues, and specific cell types, including striatal, hypothalamic, and claustrum neurons. We found considerable genetic correlations with psychiatric traits and sleep duration, and modest correlations with other sleep-related traits. Mendelian randomization identified the causal effects of insomnia on depression, diabetes, and cardiovascular disease, and the protective effects of educational attainment and intracranial volume. Our findings highlight key brain areas and cell types implicated in insomnia, and provide new treatment targets.
- Subjects :
- Male
Cell type
Quantitative Trait Loci
Disease
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Sleep Initiation and Maintenance Disorders
Mendelian randomization
Genetics
Humans
Genetic Predisposition to Disease
Gene
030304 developmental biology
Genetic association
0303 health sciences
Middle Aged
Heritability
Phenotype
Chromatin
3. Good health
Expression quantitative trait loci
Female
Sleep
030217 neurology & neurosurgery
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15461718 and 10614036
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Nature Genetics
- Accession number :
- edsair.doi.dedup.....7be8253e9175c145f85bfc241a446b52