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Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria
- Source :
- Cell reports. 23(10)
- Publication Year :
- 2018
-
Abstract
- We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight specific microbiome traits that are progressively lost with urbanization, such as the dominance of pristine fiber degraders and the low inter-individual variation. For the Bassa, this last feature is the result of their subsistence-related practices favoring microbial dispersal, such as their extensive environmental contact and the usage of untreated waters from the Usuma River. The high degree of microbial dispersal observed in the Bassa meta-community nullifies the differences between infant and adult intestinal ecosystems, suggesting that the infant-type microbiome in Western populations could be the result of microbiome-associated neotenic traits favored by urbanization. Ayeni et al. characterize the fecal microbiome and metabolome of rural Bassa and urban individuals from Nigeria, including infants. Their findings stress the loss of ancient signatures along with urbanization and support distinct trajectories of development of the intestinal ecosystem in early life, depending on human subsistence.
- Subjects :
- 0301 basic medicine
Adult
Rural Population
Adolescent
Urban Population
Nigeria
urbanization
Gut flora
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Feces
Young Adult
human evolution
microbial dispersal
Urbanization
Metabolome
Humans
Ecosystem
Microbiome
Child
Neoteny
Aged
Principal Component Analysis
Biochemistry, Genetics and Molecular Biology (all)
biology
gut microbiota
Geography
Ecology
Subsistence agriculture
Infant
subsistence pattern
Biodiversity
Middle Aged
biology.organism_classification
Diet
Gastrointestinal Microbiome
030104 developmental biology
Socioeconomic Factors
Child, Preschool
Biological dispersal
infant microbiome
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 23
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cell reports
- Accession number :
- edsair.doi.dedup.....7be602a4b8ac7083c9261cd0bb620a83