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Oxytocin-induced renin secretion by denervated kidney in anaesthetized rat
- Source :
- European Journal of Pharmacology. 454:241-247
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The effects of oxytocin on renin secretion by denervated kidney were investigated in vivo, by infusing the peptide directly into the renal artery of anaesthetized rats. Renin secretion was calculated by the renal veno-arterial difference in plasma renin activity multiplied by renal plasma flow. The intra-renal arterial (i.r.a.) infusion of oxytocin (1.5 or 15 ng/kg/min, 10 min) induced a sixfold increase in renin secretion as compared to vehicle-treated controls, without effects on renal blood flow, mean arterial blood pressure, glomerular filtration rate or natriuresis. The effect of oxytocin (1.5 ng/kg/min) was prevented by pretreatment with an oxytocin receptor antagonist, desGly-NH(2),d(CH(2))(5)[D-Tyr(2),Thr(4),Orn(8)]vasotocin] (5.6 microg/kg bolus i.v. 20 min before oxytocin infusion, followed by 2.8 microg/kg/min i.r.a.). Nadolol (2.5 mg/kg i.v.), a beta-adrenoceptor antagonist, also blocked the oxytocin-induced increase in renin secretion. These results show that oxytocin is able to stimulate renin release by activating oxytocin receptors but that beta-adrenoceptors also seem to be involved.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Vasotocin
Kidney
Oxytocin
Plasma renin activity
Natriuresis
Rats, Sprague-Dawley
chemistry.chemical_compound
Renal Artery
Internal medicine
Renin
Renin–angiotensin system
medicine
Animals
Thiopental
Anesthetics
Pharmacology
Denervation
Oxytocin receptor
Rats
medicine.anatomical_structure
Endocrinology
chemistry
Renal blood flow
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 454
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....7bd5ef614b238c867813a6248e877c24