Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature

Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare pathological lesions that can present anywhere in the central nervous system. Symptoms vary depending on the location, though they often include seizures, especially in intracranial and supratentorial lesions. A case of intracranial supratentorial CAPNON presenting with drug-resistant left temporal lobe epilepsy is reported. The patient had a history of drug-resistant focal seizures for over 36 years. The lesion was located in the left mesial temporal lobe, but hippocampal sclerosis and hippocampal invasion were not apparent. The lesion was removed without hippocampectomy, and the patient has been seizure-free for one year.
Highlights • Calcifying pseudoneoplasms of the neuraxis (CAPNON) is a rare pathological lesion. • CAPNON can present anywhere in the central nervous system. • Symptoms vary depending on the location, though they often include seizures. • A case of intracranial CAPNON presenting with medically drug-resistant left temporal lobe epilepsy is reported. • The lesion was in the left mesial temporal lobe without features of hippocampal sclerosis or hippocampal invasion. • The lesion was removed without hippocampectomy, and the patient has been seizure-free.