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Genomic Heritabilities and Correlations of 17 Traits Related to Obesity and Associated Conditions in the Japanese Population
- Source :
- G3: Genes|Genomes|Genetics, G3: Genes, Genomes, Genetics, Vol 10, Iss 7, Pp 2221-2228 (2020)
- Publication Year :
- 2020
- Publisher :
- Genetics Society of America, 2020.
-
Abstract
- Over the past few decades, obesity has become a public health issue of global concern. Even though disparities exist between human populations, e.g., the higher liver fat content of the Japanese despite a lower body mass index (BMI), studies on the genetics of obesity still largely focus on populations of European descent, leading to a dearth of genetic data on non-European populations. In this context, this study aimed to establish a broad picture of the genetic attributes of the Japanese population, by examining a representative sample of 18,889 individuals participating in the Tohoku Medical Megabank Project cohort. We applied linear mixed model methods to 17 traits related to obesity and associated diseases to estimate the heritabilities explained by common genetic variants and the genetic correlations between each pair of traits. These analyses allowed us to quantify the SNP heritability of health indicators such as BMI (0.248 ± 0.032) and HDL cholesterol (0.324 ± 0.031), and to provide one of the few estimates of the SNP heritability of cystatin C in unrelated individuals (0.260 ± 0.025). We discuss potential differences between the Japanese and people of European ancestry with respect to the genetic correlations between urinary biomarkers and adiposity traits, for which large estimates were obtained. For instance, the genetic correlations between urine potassium level and the values for weight, BMI, waist circumference, and waist-to-height ratio ranged from 0.290 to 0.559, much higher than the corresponding estimates in the UK Biobank.
- Subjects :
- Genetic correlation
Waist
Context (language use)
Polygenic model analysis
QH426-470
Biology
Investigations
Body Mass Index
Heritability
03 medical and health sciences
0302 clinical medicine
Japan
Genetics
medicine
Humans
Mass index
030212 general & internal medicine
Obesity
Molecular Biology
Genetics (clinical)
030304 developmental biology
0303 health sciences
Japanese population
Genetics of obesity
Genomics
medicine.disease
Cohort
Waist Circumference
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 21601836
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- G3: Genes|Genomes|Genetics
- Accession number :
- edsair.doi.dedup.....7ba2d851e2270fa09be022f3891ba928