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HPV16 E6 seropositivity among cancer-free men with oral, anal or genital HPV16 infection
- Source :
- Papillomavirus Research, Papillomavirus Research, Vol 2, Iss, Pp 141-144 (2016)
- Publisher :
- The Authors. Published by Elsevier B.V.
-
Abstract
- Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0–18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0–8.8%), and 24-month persistent genital HPV16-infection (1/84; 1.2%, 0.0–6.5%). This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition. Keywords: HPV, HPV16 E6 seropositivity, Oropharyngeal cancer, Anal cancer, Penile cancer
- Subjects :
- medicine.medical_specialty
HPV
viruses
Article
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Hpv16 e6
0302 clinical medicine
Virology
medicine
Anal cancer
Penile cancer
lcsh:RC109-216
Sex organ
030212 general & internal medicine
Seroconversion
Gynecology
Oropharyngeal cancer
biology
business.industry
HPV infection
Cancer
virus diseases
medicine.disease
female genital diseases and pregnancy complications
3. Good health
Infectious Diseases
030220 oncology & carcinogenesis
biology.protein
HPV16 E6 seropositivity
Antibody
business
Subjects
Details
- Language :
- English
- ISSN :
- 24058521
- Database :
- OpenAIRE
- Journal :
- Papillomavirus Research
- Accession number :
- edsair.doi.dedup.....7b82c84ce4499811b0e8a0dbb6f6c6ff
- Full Text :
- https://doi.org/10.1016/j.pvr.2016.07.003