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Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level

Authors :
Yaqiong Jia
Chunyan Li
Geng Chang
Bin Li
Yansu Guo
Weisong Duan
Meng-Meng Sun
Jixu Yu
Source :
FEBS letters. 584(13)
Publication Year :
2010

Abstract

Epigallocatechin-3-gallate (EGCG) is a major component of green tea polyphenols which displays potential properties of anticancer and neuroprotection. Here we show that protection of motor neuron by EGCG is associated with regulating glutamate level in organotypic culture of rat spinal cord. In this model, EGCG blocked glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter. This property of EGCG may be not due to its intrinsic antioxidative activity, because another antioxidant could not regulate glutamate level under the same condition. These results show that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity such as ALS.

Details

ISSN :
18733468
Volume :
584
Issue :
13
Database :
OpenAIRE
Journal :
FEBS letters
Accession number :
edsair.doi.dedup.....7b7b42c01cff88e3beecd361eb3c34b4