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Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level
- Source :
- FEBS letters. 584(13)
- Publication Year :
- 2010
-
Abstract
- Epigallocatechin-3-gallate (EGCG) is a major component of green tea polyphenols which displays potential properties of anticancer and neuroprotection. Here we show that protection of motor neuron by EGCG is associated with regulating glutamate level in organotypic culture of rat spinal cord. In this model, EGCG blocked glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter. This property of EGCG may be not due to its intrinsic antioxidative activity, because another antioxidant could not regulate glutamate level under the same condition. These results show that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity such as ALS.
- Subjects :
- Spinal cord organotypic culture
Motor neuron
Antioxidant
medicine.medical_treatment
Glutamate decarboxylase
Blotting, Western
Biophysics
Excitotoxicity
Green tea polyphenol
Glutamic Acid
Glutamate excitotoxicity
Epigallocatechin gallate
Pharmacology
medicine.disease_cause
complex mixtures
Biochemistry
Neuroprotection
Catechin
Rats, Sprague-Dawley
chemistry.chemical_compound
Organ Culture Techniques
Structural Biology
Genetics
medicine
Animals
heterocyclic compounds
Amyotrophic lateral sclerosis
Molecular Biology
Motor Neurons
Chemistry
Glutamate receptor
food and beverages
Cell Biology
medicine.disease
Immunohistochemistry
Rats
medicine.anatomical_structure
Neuroprotective Agents
Gene Expression Regulation
Spinal Cord
sense organs
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 584
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....7b7b42c01cff88e3beecd361eb3c34b4