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Casting light on molecular events underlying anti-cancer drug treatment: what can be seen from the proteomics point of view?
- Source :
- Europe PubMed Central
- Publication Year :
- 2006
-
Abstract
- Regardless of continuous advances in technology and expansion of the knowledge in the field of genomic information, cancer still remains one of the leading causes of death in developed countries for many reasons, including non-selectiveness of commonly used anti-cancer drugs that often influence non-specific rather than tumour-specific targets. As cancer cells are characterized by the ability to divide and multiply in an uncontrolled manner whereby a set of specific proteins modulate cell division processes, proteomics seems to be a suitable tool for seeking out molecular mediators of anti-cancer drugs action and resistance, thus improving chemotherapy outcome. This review will focus on the recent knowledge of the molecular mechanisms involved in the anti-cancer drugs response revealed by the proteomics tools. In addition, we will touch upon the effects of ‘ ‘ gene drugs’ ’ with p53 and p21waf1/cip1 genes on the protein complement of tumour cells assessed by the two-dimensional gel electrophoresis combined with mass spectrometry. Such studies could substantially contribute to further drug optimization prior to its clinical use and represent an important but still small step in the long way of drug discovery. However, fluctuations in protein expression, distribution, posttranslational modifications, interactions, functions and compartmentalization make it difficult to use exclusively expression proteomics data without putting it in broader biological context. Thus, the challenge today is to shift from the identification of drug response and disease biomarkers to more time-consuming process of revealing the biochemical mechanism that connects a specific protein with a disease or cellular response to a drug.
- Subjects :
- Proteomics
Drug
drug development
drug resistance
drug target
proteomics
2-DE
mass spectrometry
anti-cancer compounds
media_common.quotation_subject
Protein Array Analysis
Antineoplastic Agents
Context (language use)
610 Medicine & health
10071 Functional Genomics Center Zurich
Disease
Drug resistance
Computational biology
Biology
Bioinformatics
Mass Spectrometry
Neoplasms
Humans
2741 Radiology, Nuclear Medicine and Imaging
Electrophoresis, Gel, Two-Dimensional
Radiology, Nuclear Medicine and imaging
media_common
Drug discovery
General Medicine
Oncology
Drug development
Cancer cell
570 Life sciences
biology
2730 Oncology
U7 Systems Biology / Functional Genomics
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....7b6157110fa75ab34911293da95b9866