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Structures and functions of the inflammasome engine
- Source :
- J Allergy Clin Immunol
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity to cancer. In recent years, significant advances have been made in understanding the mechanism of inflammasome signaling using structural approaches. Here, we review inflammasomes formed by the NLRP1, NLRP3, and NLRC4 sensors, which are well characterized structurally, and discuss the structural and functional diversity among them.
- Subjects :
- 0301 basic medicine
Damp
Inflammasomes
Immunology
Caspase 1
NLR Proteins
Computational biology
Biology
Article
03 medical and health sciences
0302 clinical medicine
NLRC4
NLR Family, Pyrin Domain-Containing 3 Protein
Pyroptosis
medicine
Animals
Humans
Immunology and Allergy
Mechanism (biology)
Pathogen-associated molecular pattern
Calcium-Binding Proteins
Damage-associated molecular pattern
Inflammasome
CARD Signaling Adaptor Proteins
030104 developmental biology
Disease Susceptibility
Biomarkers
030217 neurology & neurosurgery
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....7b5ca9cb468df6a43d7e3912a3d80a7d