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Cytokines and intrathecal IgG synthesis in multiple sclerosis patients during clinical remission
- Source :
- ResearcherID, Arquivos de Neuro-Psiquiatria v.63 n.4 2005, Arquivos de neuro-psiquiatria, Academia Brasileira de Neurologia, instacron:ABNEURO, Scopus-Elsevier, Arquivos de Neuro-Psiquiatria, Volume: 63, Issue: 4, Pages: 914-919, Published: DEC 2005
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Abstract
- Cytokines and intrathecal IgG synthesis were determined in the cerebrospinal fluid (CSF) and sera to evaluate inflammatory activity in multiple sclerosis (MS) patients during clinical remission. Although the disease was stable, there had been a significant increase of proinflammatory cytokines such as TNFalpha and IFNgamma in the CSF and serum, with no significant changes of IL12 and IL10 production. The changes in the cytokine production patterns were associated with an increase of leukocytes in the CSF, as well as the presence of oligoclonal bands suggesting intrathecal IgG synthesis. These results suggest that even when the disease is clinically silent, one can observe inflammatory activity in these MS patients. Os níveis de citocinas e síntese intratecal de IgG foram dosados no líquido cefalorraquidiano (LCR) e soro, com o objetivo de avaliar a atividade inflamatória em pacientes com esclerose múltipla durante remissão clínica. Foram detectados níveis elevados de citocinas pró-inflamatórias (TNFalfa e IFNgama) no LCR e soro, sem alterações significativas na produção de IL12 e IL10. O perfil de produção das citocinas pró-inflamatórias estava associado ao aumento de leucócitos no LCR, assim como a presença de bandas oligoclonais IgG sugerindo síntese intratecal de IgG. Estes resultados sugerem que mesmo quando a doença está clinicamente silenciosa, a atividade inflamatória está presente nestes pacientes.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
IgG síntese intratecal
medicine.medical_treatment
Enzyme-Linked Immunosorbent Assay
Disease
multiple sclerosis
cerebrospinal fluid
Proinflammatory cytokine
Leukocyte Count
Multiple Sclerosis, Relapsing-Remitting
Cerebrospinal fluid
esclerose múltipla
medicine
Humans
Child
líquido cefalorraquidiano
Inflammation
business.industry
Multiple sclerosis
Oligoclonal Bands
Middle Aged
medicine.disease
cytokines
Interleukin 10
Cytokine
Neurology
Case-Control Studies
Immunoglobulin G
intrathecal IgG synthesis
Immunology
citocinas
Interleukin 12
Cytokines
Female
Tumor necrosis factor alpha
Neurology (clinical)
business
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID, Arquivos de Neuro-Psiquiatria v.63 n.4 2005, Arquivos de neuro-psiquiatria, Academia Brasileira de Neurologia, instacron:ABNEURO, Scopus-Elsevier, Arquivos de Neuro-Psiquiatria, Volume: 63, Issue: 4, Pages: 914-919, Published: DEC 2005
- Accession number :
- edsair.doi.dedup.....7b3aae63035b332d2b42e45ce15465da