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Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper

Authors :
Arup Mukherjee
Guillermo R. Castro
Magdalena Mechetti
Azucena Gómez López
Valeria Elizabeth Bosio
Source :
CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
Publication Year :
2014
Publisher :
Royal Society of Chemistry, 2014.

Abstract

Doxorubicin (Dox) was co-encapsulated with congo red (CR) in order to increase drug encapsulation and sustain the release from gel microbeads composed of alginate–carboxy methyl guar gum (68/32) for oral controlled delivery. No release of either cargo molecule from the microbeads at pH 1.2 within 90 minutes was detected. However, 62% CR and 16% Dox were released from the gels at pH 7.4 at 37 °C in 8 hours when both the cargo molecules were studied alone. Presence of CR in the formulation reduces the release of Dox by about 25–30% under the same experimental conditions. Rheological properties of the formulations have been investigated at different temperatures between 20 and 37 °C. Shear thinning behavior was observed by steady-shear flow experiments for all formulations, and no yield stress was observed for any of the formulations. The temperature effect on Alg–CMGG–Dox–CR evidenced a synergic action between Dox and CR. Dynamic frequency sweep tests were performed to study the viscoelastic properties of the formulations. The patterns observed for Alg–CMGG indicated physical gel characteristics; however, all other formulations showed behaviour typical of concentrated solutions. These results confirm the interaction of Dox and CR, and the concomitant positive effect on sustainable release in oral delivery.<br />Centro de Investigación y Desarrollo en Fermentaciones Industriales

Details

Language :
English
Database :
OpenAIRE
Journal :
CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
Accession number :
edsair.doi.dedup.....7b3801b2154ab1167407cd1d08bb5e33