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Chemoreduction for intraocular retinoblastoma in Malaysia
- Source :
- Journal of pediatric hematology/oncology. 29(1)
- Publication Year :
- 2007
-
Abstract
- In the last decade, chemotherapy in combination with focal therapy (chemoreduction) has been increasingly used in intraocular retinoblastoma to avoid enucleation and radiotherapy. The aim of this study was to assess the feasibility and outcome of chemoreduction in Malaysian children with retinoblastoma. This was a prospective study from August 2001 to January 2006. Twenty children (25 eyes) were given 4 cycles of chemoreduction, after which the response was assessed. Fourteen eyes showed a complete response, 10 eyes showed a partial response, and 1 eye had progressive disease. Twelve eyes developed progressive disease later, 9 after an initial complete response and 3 after a partial response. Overall, progressive disease occurred in 52%. There were 2 treatment failures, in Reese-Elsworth groups 3 and 4. Both eyes required enucleation. One eye in group 5 required second line chemotherapy to achieve a complete response. No eyes were irradiated. Five children (25%) defaulted follow-up, one of whom returned with disseminated disease. In conclusion, 4 cycles of chemoreduction achieved a durable complete response in only 12% of eyes. Chemoreduction is feasible in Malaysia but requires good patient compliance and close follow-up.
- Subjects :
- Male
medicine.medical_specialty
genetic structures
medicine.medical_treatment
Retinal Neoplasms
Enucleation
Intraocular Retinoblastoma
Disease-Free Survival
Carboplatin
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Disseminated disease
Prospective Studies
Prospective cohort study
Etoposide
Chemotherapy
Retinoblastoma
business.industry
Malaysia
Infant
Hematology
medicine.disease
Combined Modality Therapy
eye diseases
Surgery
Radiation therapy
Oncology
Cryotherapy
Vincristine
Pediatrics, Perinatology and Child Health
Female
sense organs
Laser Therapy
business
Progressive disease
Follow-Up Studies
Subjects
Details
- ISSN :
- 10774114
- Volume :
- 29
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric hematology/oncology
- Accession number :
- edsair.doi.dedup.....7b3732ba0008a959867c06978b9e0a45