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In depth analysis of patients with severe SARS-CoV-2 in sub-Saharan Africa demonstrates distinct clinical and immunological profiles
- Source :
- Nature Communications, medRxiv, article-version (status) pre, article-version (number) 2
- Publication Year :
- 2021
-
Abstract
- Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.<br />Clinical management of COVID-19 in resource-poor settings has distinct challenges and detailed patient characterisation is needed. Here, the authors describe the clinical and immunological profiles of patients at a hospital in Malawi with confirmed and suspected COVID-19.
- Subjects :
- Adult
Male
Chemokine
medicine.drug_class
medicine.medical_treatment
Antibiotics
Disease
medicine.disease_cause
Antibodies
Dexamethasone
Article
Immune system
Streptococcus pneumoniae
mental disorders
Humans
Medicine
Clinical microbiology
Pandemics
Africa South of the Sahara
biology
Coinfection
business.industry
SARS-CoV-2
Infectious-disease diagnostics
COVID-19
Middle Aged
Anti-Bacterial Agents
COVID-19 Drug Treatment
Cytokine
Immunoglobulin M
Staphylococcus aureus
Viral infection
Immunoglobulin G
Immunology
biology.protein
Cytokines
Female
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- medRxiv : the preprint server for health sciences
- Accession number :
- edsair.doi.dedup.....7b2f497b44cd8a58a35b9eabb7c06cc5