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Alpha- and beta-cell abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes
- Publication Year :
- 2014
-
Abstract
- New recommendations for the use of glycated haemoglobin A1c (HbA1c) to diagnose prediabetes and type 2 diabetes have changed the constitution of the two populations. We aimed to investigate the pathophysiological characteristics of individuals with HbA1c-defined prediabetes and type 2 diabetes, respectively. Ten subjects with HbA1c-defined prediabetes, i.e. HbA1c from 5.7 to 6.4 % (39–46 mmol/mol), eight newly diagnosed patients with HbA1c-defined type 2 diabetes [HbA1c ≥6.5 % (≥48 mmol/mol)], and ten controls with HbA1c lower than 5.7 % (
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Incretin
Type 2 diabetes
Incretins
Glucagon
Prediabetic State
Endocrinology
Insulin-Secreting Cells
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Humans
Insulin
Prediabetes
Glycated Hemoglobin
Glucose tolerance test
C-Peptide
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
Glucagon-Secreting Cells
Female
business
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7b2d41eff56f95e53c0d78711292231e