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Cellular cardiomyoplasty and cardiac tissue engineering for myocardial therapy☆
- Source :
- Advanced Drug Delivery Reviews. 62:784-797
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Heart diseases, including myocardial infarction (MI) and congestive heart failure (CHF), have high mortality rates. Both MI and CHF are characterized by cardiac muscle damage caused by massive cardiomyocyte death and reduced cardiac function. Cellular therapy aimed at using cells to improve cardiac function and/or regenerate new myocardium, has been extensively investigated for cardiac repair. Two strategies have been currently taken for cellular transplantation, including in situ cellular cardiomyoplasty and cardiac tissue engineering. The in situ cellular cardiomyoplasty strategy delivers cells directly into the infarcted myocardium. A variety of cell types has been shown to be beneficial in cardiac repair. However, this strategy is limited in terms of cell retention, survival of the engrafted cells, cell differentiation, and integration of transplanted cells with host tissue. Cardiac tissue engineering is an alternate strategy to in situ cellular cardiomyoplasty, which is designed to repair infarcted myocardium using cells, biomaterials and regulative factors (for example growth factors). There are currently various approaches for cardiac tissue engineering, such as, in situ delivering cells with injectable biomaterials into the infarcted myocardium, in vitro engineering of contractile tissue constructs followed by in vivo implantation, in vitro engineering of stem cell loaded tissue constructs for in vivo myocardium regeneration, and cell sheet tissue engineering. This review provides a comprehensive progress of in situ cellular cardiomyoplasty and cardiac tissue engineering for cardiac repair.
- Subjects :
- Cardiac function curve
medicine.medical_specialty
Cell Transplantation
Myocardial Infarction
Pharmaceutical Science
Cell therapy
Tissue engineering
Internal medicine
Cellular cardiomyoplasty
Animals
Humans
Regeneration
Medicine
Myocyte
Myocytes, Cardiac
cardiovascular diseases
Cardiomyoplasty
Heart Failure
Tissue Engineering
business.industry
Myocardium
Regeneration (biology)
Cardiac muscle
medicine.disease
medicine.anatomical_structure
Heart failure
cardiovascular system
Cardiology
business
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 0169409X
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....7b25ec636d29a178f866bc008a744b5c