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Molecular targets for diagnostic and intraoperative imaging of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX treatment
- Source :
- Scientific reports, 10(1):16211. Nature Publishing Group, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020), Scientific Reports, 10(1). NATURE RESEARCH
- Publication Year :
- 2020
-
Abstract
- Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tissue and therapy induced fibrosis (TIF). Consequently, resections with tumor positive margins and subsequent early post-operative recurrences occur and patients eligible for potential radical resection could be missed. To optimize patient selection and monitor results of neoadjuvant treatment, PDAC-specific diagnostic and intraoperative molecular imaging methods are required. This study aims to evaluate molecular imaging targets for PDAC after neoadjuvant FOLFIRINOX treatment. Expression of integrin αvβ6, carcinoembryonic antigen cell adhesion molecule 5 (CEACAM5), mesothelin, prostate-specific membrane antigen (PSMA), urokinase-type plasminogen activator receptor, fibroblast activating receptor, integrin α5 subunit and epidermal growth factor receptor was evaluated using immunohistochemistry. Immunoreactivity was determined using the semiquantitative H-score. Resection specimens from patients after neoadjuvant FOLFIRINOX treatment containing PDAC (n = 32), tumor associated pancreatitis (TAP) and TIF (n = 15), normal pancreas parenchyma (NPP) (n = 32) and tumor positive (n = 24) and negative (n = 56) lymph nodes were included. Integrin αvβ6, CEACAM5, mesothelin and PSMA stainings showed significantly higher expression in PDAC compared to TAP and NPP. No expression of αvβ6, CEACAM5 and mesothelin was observed in TIF. Integrin αvβ6 and CEACAM5 allow for accurate metastatic lymph node detection. Targeting integrin αvβ6, CEA, mesothelin and PSMA has the potential to distinguish vital PDAC from fibrotic tissue after neoadjuvant FOLFIRINOX treatment. Integrin αvβ6 and CEACAM5 detect primary tumors and tumor positive lymph nodes.
- Subjects :
- 0301 basic medicine
endocrine system diseases
FOLFIRINOX
lcsh:Medicine
03 medical and health sciences
0302 clinical medicine
Carcinoembryonic antigen
Carcinoma
medicine
Mesothelin
Epidermal growth factor receptor
lcsh:Science
Lymph node
Multidisciplinary
biology
business.industry
Standard treatment
lcsh:R
medicine.disease
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Cancer research
Immunohistochemistry
lcsh:Q
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific reports, 10(1):16211. Nature Publishing Group, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020), Scientific Reports, 10(1). NATURE RESEARCH
- Accession number :
- edsair.doi.dedup.....7b25360a5f220fb7074f6acda8b32f4d