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SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations
- Source :
- PLoS Pathogens, Vol 9, Iss 1, p e1003011 (2013), PLoS Pathogens
- Publication Year :
- 2013
- Publisher :
- Public Library of Science, 2013.
-
Abstract
- Pathogenesis studies of SIV infection have not been performed to date in wild monkeys due to difficulty in collecting and storing samples on site and the lack of analytical reagents covering the extensive SIV diversity. We performed a large scale study of molecular epidemiology and natural history of SIVagm infection in 225 free-ranging AGMs from multiple locations in South Africa. SIV prevalence (established by sequencing pol, env, and gag) varied dramatically between infant/juvenile (7%) and adult animals (68%) (p<br />Author Summary We simultaneously assessed, for the first time in a natural host, the epidemiology, diversity and natural history of SIVagmVer infection in wild vervet populations from South Africa. We report that African green monkeys (AGMs) have likely been infected with SIVagm for a long period, ranging from the time of their speciation to Plio-Pleistocene migrations, refuting previous molecular clock calculations suggesting SIVagm to be of recent occurrence. As a result of virus-host coadaptation, SIVagmVer infection is characterized by a lack of disease progression in spite of robust viral replication. We show that very active SIVagm transmission in adult AGMs contrasts with a very limited transmission to their offspring, in spite of massive exposure to SIVagm both in utero and through breastfeeding. The observation that some AGMs remain uninfected in spite of life-long exposure to SIVagm identifies wild vervets as an acceptable animal model for the exposed uninfected individuals, which can be used to identify correlates of resistance to HIV/SIV infection.
- Subjects :
- Male
animal diseases
viruses
Simian Acquired Immunodeficiency Syndrome
Pathogenesis
medicine.disease_cause
law.invention
Serology
South Africa
Immunodeficiency Viruses
Mutation Rate
law
Chlorocebus aethiops
Biology (General)
Polymerase chain reaction
Recombination, Genetic
Genetics
0303 health sciences
Ecology
Viral Load
Host-Pathogen Interaction
Host-Pathogen Interactions
Female
Simian Immunodeficiency Virus
Viral load
Research Article
QH301-705.5
Molecular Sequence Data
Immunology
Biology
Microbiology
Microbial Ecology
Evolution, Molecular
03 medical and health sciences
Phylogenetics
Virology
medicine
Animals
Molecular Biology
Repetitive Sequences, Nucleic Acid
030304 developmental biology
Base Sequence
Molecular epidemiology
030306 microbiology
Immunity
Genetic Variation
Simian immunodeficiency virus
RC581-607
Animal Models of Infection
Parasitology
Viral replication
Immunologic diseases. Allergy
Viral Transmission and Infection
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Database :
- OpenAIRE
- Journal :
- PLoS Pathogens, Vol 9, Iss 1, p e1003011 (2013), PLoS Pathogens
- Accession number :
- edsair.doi.dedup.....7b1e7f3faf3c7d3f54e1cc32bc709d80