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Effectiveness of a 595-nm Pulsed Dye Laser for the Treatment of Basal Cell Carcinoma Using One Double-Stacked Pulse Session: A Randomized, Double-Blinded Controlled Trial
- Source :
- Dermatologic Surgery. 47:630-633
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background Surgical and nonsurgical methods are used for treating basal cell carcinoma (BCC). Few randomized controlled trials exist on the effectiveness of the pulsed dye laser (PDL) on BCC treatment. Objective We investigated the effectiveness of PDL treatment in a single session for the management of nodular and superficial BCCs on the trunk and extremities of adults using a randomized, double-blind, controlled technique. Methods We used settings of fluence 7.5 J/cm2, 3-ms pulse duration, no dynamic cooling, 10-mm spot size, 10% overlap between pulses, and 2 stacked pulses on a 595-nm wavelength laser. Histopathologic clearance on excision of tumor with 4-mm margins was the primary outcome measure. Results Twenty-four patients were included in the study, with 14 in the laser treatment group and 10 patients in the sham/control group. In total, 10/14 (71.4%) of the tumors in the treatment group were successfully treated with no residual tumor on excisional specimen histology, compared with 3/10 (30.0%) of the control group (p = .045). Conclusion Our study shows that PDL may be an effective treatment for low-risk BCCs of the trunk and extremities, but the cure rate is lower than those of other treatments for BCC. Thus, PDL under the current settings cannot be recommended.
- Subjects :
- Adult
Male
Skin Neoplasms
Double blinded
Lasers, Dye
Dermatology
law.invention
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
law
medicine
Humans
Basal cell carcinoma
Aged
Dye laser
business.industry
Pulse (signal processing)
Pulse duration
General Medicine
Middle Aged
Laser
medicine.disease
Trunk
Carcinoma, Basal Cell
030220 oncology & carcinogenesis
Female
Surgery
Nuclear medicine
business
Subjects
Details
- ISSN :
- 15244725 and 10760512
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Dermatologic Surgery
- Accession number :
- edsair.doi.dedup.....7b1a926c24904d3094cec355ad8980ad