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Early Occurrence of Apoptosis in Lymphoid Tissues from Chickens Infected with Strains of Newcastle Disease Virus of Varying Virulence

Authors :
Jian Zhang
Claudio L. Afonso
L. Harrison
Leonardo Susta
Cathy A. Brown
Source :
Journal of Comparative Pathology. 145:327-335
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

Newcastle disease virus (NDV), the causative agent of Newcastle disease, is a prevalent problem in the poultry industry and often the cause of severe economic loss. There are many strains of the virus and these have varying virulence. The most virulent strains cause systemic lesions of lymphoid tissues, with necrosis and severe lymphoid depletion. Less virulent strains do not cause as much necrosis, but may predispose to secondary infection with other pathogens. Apoptosis or programmed cell death, has been demonstrated to play a role in the pathogenesis of other paramyxovirus infections, notably those caused by measles and canine distemper viruses. To investigate the role of apoptosis in lymphoid organs during NDV infection, immunohistochemistry for determination of expression of caspase-3, a marker of imminent apoptosis, was performed on formalin-fixed paraffin wax-embedded tissues (spleen, thymus, caecal tonsils and bursa of Fabricius) from 4-week-old chickens infected with NDV strains of varying virulence 2 days previously. The amount of apoptosis was proportional to the severity of the clinical disease elicited by the strains.

Details

ISSN :
00219975
Volume :
145
Database :
OpenAIRE
Journal :
Journal of Comparative Pathology
Accession number :
edsair.doi.dedup.....7b183395e1097d2a3c5aa4eef4d7de84
Full Text :
https://doi.org/10.1016/j.jcpa.2011.03.005