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Multicentre European study for the treatment of advanced emphysema with bronchial valves
- Source :
- The European respiratory journal. 39(6)
- Publication Year :
- 2012
-
Abstract
- This multicentre, blinded, sham-controlled study was performed to assess the safety and effectiveness of bronchial valve therapy using a bilateral upper lobe treatment approach without the goal of lobar atelectasis. Patients with upper lobe predominant severe emphysema were randomised to bronchoscopy with (n = 37) or without (n = 36) IBV Valves for a 3-month blinded phase. A positive responder was defined as having both a ≥ 4-point improvement in St George's Respiratory Questionnaire (SGRQ) and a lobar volume shift as measured by quantitative computed tomography. At 3 months, there were eight (24%) positive responders in the treated group versus none (0%) in the control group (p = 0.002). Also, there was a significant shift in volume in the treated group from the upper lobes (mean ± SD -7.3 ± 9.0%) to the non-treated lobes (6.7 ± 14.5%), with minimal change in the control group (p0.05). Mean SGRQ total score improved in both groups (treatment: -4.3 ± 16.2; control: -3.6 ± 10.7). The procedure and devices were well tolerated and there were no differences in adverse events reported in the treatment and control groups. Treatment with bronchial valves without complete lobar occlusion in both upper lobes was safe, but not effective in the majority of patients.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Atelectasis
Severity of Illness Index
Bronchoscopy
Surveys and Questionnaires
Occlusion
medicine
Humans
Quantitative computed tomography
Respiratory system
Adverse effect
Aged
Treated group
medicine.diagnostic_test
business.industry
Endobronchial valve
Middle Aged
medicine.disease
Surgery
Europe
Treatment Outcome
Pulmonary Emphysema
Anesthesia
Quality of Life
Female
business
Subjects
Details
- ISSN :
- 13993003
- Volume :
- 39
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The European respiratory journal
- Accession number :
- edsair.doi.dedup.....7b0a9ec790e29598166b96b0ca169a3d