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Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- The synthetic compound fasentin has been described as a modulator of GLUT-1 and GLUT-4 transporters, thus inhibiting glucose uptake in some cancer cells. Endothelial glucose metabolism has been recently connected to angiogenesis and it is now an emerging topic in scientific research. Indeed, certain compounds with a known effect on glucose metabolism have also been shown to inhibit angiogenesis. In this work we tested the capability of fasentin to modulate angiogenesis in vitro and in vivo. We show that fasentin inhibited tube formation in endothelial cells by a mechanism that involves a negative effect on endothelial cell proliferation and invasion, without affecting other steps related to the angiogenic process. However, fasentin barely decreased glucose uptake in human dermal microvascular endothelial cells and the GLUT-1 inhibitor STF-31 failed to inhibit tube formation in these cells. Therefore, this modulatory capacity on endothelial cells function exerted by fasentin is most likely independent of a modulation of glucose metabolism. Taken together, our results show a novel biological activity of fasentin, which could be evaluated for its utility in cancer and other angiogenesis-dependent diseases.
- Subjects :
- Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation [Medical Subject Headings]
Angiogenesis
Pyridines
Endothelial cells
Glucose uptake
Cellular differentiation
Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]
lcsh:Medicine
Chick Embryo
Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines [Medical Subject Headings]
Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement [Medical Subject Headings]
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Neovascularization
Cell Movement
Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Cardiovascular Physiological Processes::Neovascularization, Physiologic [Medical Subject Headings]
Organisms::Eukaryota::Animals [Medical Subject Headings]
Anilides
lcsh:Science
Anilidas
Cell proliferation
Cells, Cultured
Anatomy::Cells::Epithelial Cells::Endothelial Cells::Human Umbilical Vein Endothelial Cells [Medical Subject Headings]
Tube formation
Multidisciplinary
Chemistry
Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Growth::Cell Growth Processes::Cell Proliferation [Medical Subject Headings]
Cell Differentiation
Anatomy::Animal Structures::Embryo, Nonmammalian::Chick Embryo [Medical Subject Headings]
Cell biology
Endothelial stem cell
MCF-7 Cells
Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::MCF-7 Cells [Medical Subject Headings]
medicine.symptom
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminants::Cattle [Medical Subject Headings]
Proliferación celular
Neovascularization, Physiologic
Article
Target identification
medicine
Human Umbilical Vein Endothelial Cells
Animals
Humans
Chemicals and Drugs::Organic Chemicals::Amides::Anilides [Medical Subject Headings]
Cell Proliferation
Cell growth
lcsh:R
Células endoteliales
Glucose
Anatomy::Cells::Cells, Cultured [Medical Subject Headings]
Glucosa
Cancer cell
Cattle
lcsh:Q
Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HeLa Cells [Medical Subject Headings]
Tumour angiogenesis
HeLa Cells
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....7b097a600bf71036a7d30f9a11fa7e36