Back to Search
Start Over
Antimicrobial nanomedicine for ocular bacterial and fungal infection
- Source :
- Drug Delivery and Translational Research. 11:1352-1375
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Ocular infection induced by bacteria and fungi is a major cause of visual impairment and blindness. Topical administration of antibiotics remains the first-line treatment, as effective eradication of pathogens is the core of the anti-infection strategy. Whereas, eye drops lack efficiency and have relatively low bioavailability. Intraocular injection may cause concurrent ocular damage and secondary infection. In addition, antibiotic-based management can be limited by the low sensitivity to multidrug-resistant bacteria. Nanomedicine is proposed as a prospective, effective, and noninvasive platform to mediate ocular delivery and combat pathogen or even resistant strains. Nanomedicine can not only carry antimicrobial agents to fight against pathogens but also directly active microbicidal capability, killing pathogens. More importantly, by modification, nanomedicine can achieve enhanced residence time and release time on the cornea, and easy penetration through corneal tissues into anterior and posterior segments of the eye, thus improving the therapeutic effect for ocular infection. In this review, several categories of antimicrobial nanomedicine are systematically discussed, where the efficiency and possibility of further embellishment and improvement to adapt to clinical use are also investigated. All in all, novel antimicrobial nanomedicine provides potent and prospective ways to manage severe and refractory ocular infections.
- Subjects :
- genetic structures
medicine.drug_class
Secondary infection
Antibiotics
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
Release time
Cornea
03 medical and health sciences
0302 clinical medicine
Anti-Infective Agents
medicine
Humans
Prospective Studies
Pathogen
Bacteria
Infection induced
business.industry
021001 nanoscience & nanotechnology
Antimicrobial
eye diseases
Anti-Bacterial Agents
Nanomedicine
medicine.anatomical_structure
Mycoses
Immunology
sense organs
0210 nano-technology
business
Subjects
Details
- ISSN :
- 21903948 and 2190393X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Drug Delivery and Translational Research
- Accession number :
- edsair.doi.dedup.....7afd6ef795780a99626eed146780a175