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A study of zinc distribution in human serum
- Source :
- Bioinorganic Chemistry. 5:211-218
- Publication Year :
- 1976
- Publisher :
- Elsevier BV, 1976.
-
Abstract
- The partition of zinc in human serum between two major zinc-binding proteins, albumin and alpha2-macroglobulin, was studied in 28 control subjects and in 156 hospitalized patients. Albumin-bound zinc was both the major and the more dynamic of the serum zinc components. Over a wide range of values the concentrations of albumin-bound zinc and total serum zinc were highly correlated (r=0.91) with each other, as were concentrations of albumin and albumin-bound zinc (r=0.69). alpha2-Macroglobulin-bound zinc was not strongly correlated either with total serum zinc or with the serum concentration of alpha2-macroglobulin. Twenty-four hour urinary excretion of zinc was not correlated with any of the serum zinc parameters. To a large extent it appears that total serum zinc concentration reflects serum albumin concentration.
- Subjects :
- medicine.medical_specialty
Binding Sites
biology
Chemistry
Hospitalized patients
Spectrophotometry, Atomic
Serum albumin
Albumin
chemistry.chemical_element
General Medicine
Zinc
Plasma protein binding
Control subjects
Biochemistry
Endocrinology
Urinary excretion
Internal medicine
medicine
biology.protein
Humans
Distribution (pharmacology)
alpha-Macroglobulins
Serum Albumin
Protein Binding
Subjects
Details
- ISSN :
- 00063061
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioinorganic Chemistry
- Accession number :
- edsair.doi.dedup.....7af32b0d68c30b513d5d6a4c34d496a4