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Interferon-γ release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a systematic review and meta-analysis
- Source :
- Europe PubMed Central, Università degli studi di Firenze-IRIS, Scopus-Elsevier
- Publication Year :
- 2012
-
Abstract
- Data regarding the use of Interferon-gamma release assays (IGRAs) for tuberculosis diagnosis are accumulating. We systematically searched PubMed, EMBASE and Cochrane and performed pooled estimates of sensitivity and specificity of QuantiFERON-TB Gold In Tube (QFT-G-IT) and T-SPOT. TB compared to tuberculin skin test (TST). For studies assessing sensitivity, children had to have active tuberculosis. Specificity data were derived from children classified as non-infected. Eleven studies were included in the sensitivity analysis for TST, 10 for QFT-G-IT, and 9 for T-SPOT.TB. Eight studies were included in specificity analysis for TST, 8 for QFT-G-IT, and 7 for T-SPOT.TB. Pooled QFT-G-IT sensitivity was 0.79 (95%CI:0.70–0.89) pooled T-SPOT.TB sensitivity was 0.74 (95%CI:0.59–0.90) and pooled TST sensitivity was 0.82 (95%CI:0.72–0.93). Pooled QFT-G-IT and T-SPOT.TB specificities were 0.95 (95%CI:0.93–0.97) and 0.96 (95%CI:0.93–1.00), respectively. Pooled TST specificity was significantly lower 0.83 (95%CI:0.74–0.92). IGRA performance in children showed no better sensitivity than TST, but higher specificity.
- Subjects :
- medicine.medical_specialty
Tuberculosis
Immunology
Tuberculin
Bioinformatics
Sensitivity and Specificity
Mycobacterium tuberculosis
Interferon-gamma
Interferon γ
Tuberculosis diagnosis
Predictive Value of Tests
Internal medicine
medicine
Immunology and Allergy
Humans
Lymphocytes
Child
Pharmacology
biology
business.industry
Tuberculin Test
Age Factors
Skin test
bacterial infections and mycoses
medicine.disease
biology.organism_classification
Predictive value of tests
Meta-analysis
business
Biomarkers
Interferon-gamma Release Tests
Subjects
Details
- ISSN :
- 03946320
- Volume :
- 25
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of immunopathology and pharmacology
- Accession number :
- edsair.doi.dedup.....7af2a89636e479776dde2f872b82155f