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A Synthetic Polymeric Biolubricant Imparts Chondroprotection in a Rat Meniscal Tear Model
- Publication Year :
- 2018
-
Abstract
- Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one®) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control.
- Subjects :
- Male
Biocompatibility
Knee Joint
medicine.medical_treatment
Biophysics
Bioengineering
Osteoarthritis
Knee Injuries
Polyenes
010402 general chemistry
01 natural sciences
Article
Cell Line
Injections, Intra-Articular
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Chondrocytes
In vivo
Hyaluronidase
Hyaluronic acid
Synovial Fluid
medicine
Synovial fluid
Animals
Humans
Meniscus
Furans
Saline
030203 arthritis & rheumatology
Viscosupplements
Chemistry
medicine.disease
Bovine Cartilage
0104 chemical sciences
Biomechanical Phenomena
Mechanics of Materials
Rats, Inbred Lew
Ceramics and Composites
NIH 3T3 Cells
medicine.drug
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7af06e8b465c9df4baa961894fb34a12