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Evaluation of the definitions of 'high-risk' cutaneous squamous cell carcinoma using the american joint committee on cancer staging criteria and national comprehensive cancer network guidelines
- Source :
- Journal of Skin Cancer, Journal of Skin Cancer, Vol 2014 (2014)
- Publication Year :
- 2014
-
Abstract
- Recent guidelines from the American Joint Committee on Cancer (AJCC) and National Comprehensive Cancer Network (NCCN) have been proposed for the assessment of “high-risk” cutaneous squamous cell carcinomas (cSCCs). Though different in perspective, both guidelines share the common goals of trying to identify “high-risk” cSCCs and improving patient outcomes. Thus, in theory, both definitions should identify a similar proportion of “high-risk” tumors. We sought to evaluate the AJCC and NCCN definitions of “high-risk” cSCCs and to assess their concordance.Methods. A retrospective review of head and neck cSCCs seen by an academic dermatology department from July 2010 to November 2011 was performed.Results. By AJCC criteria, most tumors (n=211,82.1%) were of Stage 1; 46 tumors (13.9%) were of Stage 2. Almost all were of Stage 2 due to size alone (≥2 cm); one tumor was “upstaged” due to “high-risk features.” Using the NCCN taxonomy, 231 (87%) of tumors were “high-risk.”Discussion. This analysis demonstrates discordance between AJCC and NCCN definitions of “high-risk” cSCC. Few cSCCs are of Stage 2 by AJCC criteria, while most are “high-risk” by the NCCN guidelines. While the current guidelines represent significant progress, further studies are needed to generate a unified definition of “high-risk” cSCC to optimize management.
- Subjects :
- Oncology
Retrospective review
medicine.medical_specialty
Pathology
Cutaneous squamous cell carcinoma
Article Subject
business.industry
Concordance
Dermatology department
MEDLINE
Dermatology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
lcsh:RC254-282
Internal medicine
medicine
Head and neck
business
Cancer staging
Research Article
Subjects
Details
- ISSN :
- 20902905
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Journal of skin cancer
- Accession number :
- edsair.doi.dedup.....7ae629638c50093efc3668676a03162d