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Plasma virome and the risk of blood-borne infection in persons with substance use disorder
- Source :
- Nature communications, vol 12, iss 1, Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- There is an urgent need for innovative methods to reduce transmission of bloodborne pathogens like HIV and HCV among people who inject drugs (PWID). We investigate if PWID who acquire non-pathogenic bloodborne viruses like anelloviruses and pegiviruses might be at greater risk of acquiring a bloodborne pathogen. PWID who later acquire HCV accumulate more non-pathogenic viruses in plasma than matched controls who do not acquire HCV infection. Additionally, phylogenetic analysis of those non-pathogenic virus sequences reveals drug use networks. Here we find first in Baltimore and confirm in San Francisco that the accumulation of non-pathogenic viruses in PWID is a harbinger for subsequent acquisition of pathogenic viruses, knowledge that may guide the prioritization of the public health resources to combat HIV and HCV.<br />Spread of bloodborne infections, such as HCV and HIV, is a problem, particularly amongst people who inject drugs (PWID). Here, the authors describe and then confirm in observational PWID cohorts that those with more non-pathogenic viruses in plasma were more likely later to acquire HCV than PWID who had fewer of these non-pathogenic viruses.
- Subjects :
- Male
General Physics and Astronomy
Hepatitis
Plasma
2.2 Factors relating to the physical environment
Aetiology
Phylogeny
Multidisciplinary
Hepatitis C virus
Virome
Transmission (medicine)
Liver Disease
Substance Abuse
virus diseases
Hepatitis C
Substance abuse
Knowledge
Infectious Diseases
Anelloviruses
Blood borne infection
HIV/AIDS
Female
Public Health
Infection
Adult
Prioritization
Drug Abuse (NIDA Only)
medicine.medical_specialty
Viral epidemiology
Substance-Related Disorders
Science
Chronic Liver Disease and Cirrhosis
Anelloviridae
Article
General Biochemistry, Genetics and Molecular Biology
Virus
Young Adult
Hepatitis - C
Blood-Borne Pathogens
medicine
Humans
Human virome
Amino Acid Sequence
Clinical microbiology
Blood-Borne Infections
business.industry
Public health
General Chemistry
medicine.disease
Virology
Emerging Infectious Diseases
Good Health and Well Being
Metagenomics
Digestive Diseases
business
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....7abcc92505ee950fd9f8b7df76718a0d