Photobiomodulation Therapy Improves Postoperative Pain and Edema in Third Molar Surgeries: A Randomized, Comparative, Double-Blind, and Prospective Clinical Trial

Made available in DSpace on 2022-05-01T10:03:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 Purpose: Laser light has biological effects that can modulate inflammatory processes. Thus, this study aimed to evaluate the effects of photobiomodulation (PBM) therapy on pain, edema, and trismus after the extraction of retained third molars. Methods: A split-mouth, double-blind, randomized clinical trial (RCT) was conducted in 13 patients with similar bilateral third molars who received intraoral application PBM therapy at 4 points with a diode laser at 810 nm wavelength, 6 J (100 mW, 60 seconds/point) on 1 side (the PBM side); and laser irradiation simulation on the other side (SHAM side). The pain was assessed through visual analog scale (VAS) at 0, 12, 24, 48, and 72 hours, number of analgesic-relief (NAR), and mean time of first analgesic use; edema, through VAS, and linear facial measurements at 0, 24, 48, and 72 hours; and trismus, through the mouth opening measurements at 0, 24, 48, and 72 hours. The repeated-measures analysis was applied to assess the effect of the treatment, followed by Tukey's post hoc test for multiple comparisons (P Research Fellow Skeletal Biology Research Center Department of Oral and Maxillofacial Surgery Massachusetts General Hospital (MGH) Harvard School of Dental Medicine Professor of Department of Biomedical Surgical and Dental Sciences Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico University of Milan Professor of Oral & Maxillo Facial Surgery Faculty of Dentistry Department of Clinic and Surgery Federal University of Alfenas (UNIFAL) Professor of Periodontology School of Dentistry Department of Diagnose and Surgery São Paulo State University (UNESP) Professor of Oral & Maxillo Facial Surgery School of Dentistry Department of Diagnose and Surgery São Paulo State University (UNESP) PhD Student Department of Diagnose and Surgery São Paulo State University (UNESP) School of Dentistry Professor of Periodontology School of Dentistry Department of Diagnose and Surgery São Paulo State University (UNESP) Professor of Oral & Maxillo Facial Surgery School of Dentistry Department of Diagnose and Surgery São Paulo State University (UNESP)