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The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan
- Source :
- International Journal of Clinical Oncology, Int J Clin Oncol
- Publication Year :
- 2021
- Publisher :
- Springer Singapore, 2021.
-
Abstract
- Background Since June 2019, cancer genomic profiling (CGP) tests have been reimbursed by the National Health Insurance system in Japan, with restrictions for government-designated hospitals with a molecular tumor board composed of multidisciplinary specialists, known as an expert panel (EP). The standardization of EPs is a critical challenge for implementing precision oncology in the clinical setting. Methods Data on consecutive cases who underwent the CGP tests at 11 core hospitals between June 2019 and January 2020 were collected. We evaluated the proportions of cases that received genomically matched treatments, including investigational new drugs (INDs) based on CGP results, and/or for which genetic counseling was recommended. Two simulated cases were annotated by each EP. The annotated reports were then centrally assessed. Results Each EP mainly discussed the applicability to genomically matched treatments and the necessity of performing genetic counseling. A pre-review of the report by key members in each EP reportedly made the EP conference more interactive and efficient, and thereby saved time. A total of 747 cases underwent CGP tests, 28 cases (3.7%) received genomically matched treatment, and 17 cases (2.3%) were referred for genetic counseling. Annotated reports for the simulated cases varied across the EPs, particularly the number of recommended IND trials, which seemed to be associated with the actual number of participants in IND trials. Conclusions This investigation provides reference data for the application of precision oncology in a clinical setting. Further investigations on the standardization of clinical annotations are warranted.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Genomic profiling
Genetic counseling
Core hospitals
03 medical and health sciences
Special Article
0302 clinical medicine
Japan
Neoplasms
Humans
Medicine
Genomic medicine
Tumor board
Precision Medicine
Comprehensive genomic profiling tests
Expert panel
business.industry
Correction
Cancer
Precision oncology
Genomics
Hematology
General Medicine
medicine.disease
Hospitals
030104 developmental biology
Oncology
National health insurance
Investigational new drug trials
030220 oncology & carcinogenesis
Family medicine
Surgery
business
Subjects
Details
- Language :
- English
- ISSN :
- 14377772 and 13419625
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....7aaca2d9c7876e11c7f886be1ccca5ff